|Inflamation and heart disease|
How do anti-inflammatory drugs relate to heart disease?
There is growing evidence that inflammation of blood vessels is important for the development of heart disease and stroke. Aspirin has been proven to prevent cardiovascular events, but it remains uncertain whether this benefit relates to aspirin's relatively mild anti-inflammatory properties or its effects on platelets and blood clotting. Recently, a new more potent class of anti-inflammatory drugs has become available known as cyclo-oxygenase-2 (COX-2) inhibitors. These drugs have fewer adverse effects on the stomach than aspirin. In addition, they may specifically inhibit the production of harmful vasoconstrictor substances in the blood vessel wall and improve blood vessel function.
Why are we studying cyclo-oxygenase-2 inhibitors?
This study will determine whether anti-inflammatory treatment improves endothelial function and will help us understand how inflammation affects cardiac risk.We expect this study will increase our understanding of blood vessel function in atherosclerosis and may lead to improved treatment of patients.
What does the study involve?
In this study, vasodilation of the brachial artery (the main blood vessel in the arm) will be studied non-invasively using ultrasound. Patients will be treated with celecoxib or placebo for one week. Ultrasound studies will be performed before and after treatment. We will also examine blood and urine samples for evidence inflammation and COX-2 inhibition.
Who is eligible to participate?
Patients with coronary risk factors (hypertension, hypercholesterolemia, or diabetes) and normal subjects will be recruited into the study.
How long will the study last?
The study will last 1 week. There will be 2 visits each of the will last approximately 45 minutes.
What are the risks involved?
There are no risks associated with the ultrasound. We will be obtaining a blood sample which could cause a momentary discomfort and there is a slight chance of bruising and infection. Celecoxib is approved for the treatment of arthritis by the FDA. It has the potential to cause stomach discomfort, bleeding, or ulcers, but this risk if generally much lower than that for other non-steroidal anti-inflammatory drugs. If you have a history of an allergy to aspirin or other non-steroidal anti-inflammatory drugs, you will not be eligible for this study.
Who do I contact to participate?