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Research

Recent Publications

Our clinician-researchers publish frequently in leading medical journals and use their research to bring innovation in teaching geriatrics and improving the care of vulnerable older adults. Included below (categorized by topic) are articles published in 2008, 2009 and 2010 authored by one or more BMC clinician-researchers in the Section of Geriatrics.   

Alzheimer's Disease
Anti-Aging
Cancer Care in Older Adults
Ethical Considerations
Exceptional Longevity
Geriatric Education
Geriatric Medicine
Health Literacy
Research Methods

Alzheimer's Disease

Chao S, Roberts JS, Marteau TM, Silliman R, Cupples LA, Green RC. Health behavior changes after genetic risk assessment for Alzheimer’s Disease: The REVEAL Study. Alz Dis Assoc Disord 2008;22:94-97.

Anti-Aging

Olshansky SJ, Perls TT. New developments in the illegal provision of growth hormone for "anti-aging" and bodybuilding. JAMA 2008;299:2792-94.

Cancer Care in Older Adults

Hanchate AD, Clough-Gorr KM, Ash AS, Thwin SS, Silliman RA. Longitudinal patterns in survival, comorbidity, healthcare utilization and quality of care among older women following breast cancer diagnosis. J Gen Intern Med 2010.

Schonberg MA, Marcantonio ER, Li D, Silliman RA, Ngo L, McCarthy EP. Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival. J Clin Oncol 2010; 28(12)2038-45.

Lash TL, Cronin-Fenton D, Ahern TP, Rosenberg CL, Lunetta KL, Silliman RA, Hamilton-Dutoit S, Garne JP, Ewertz M, Sørensen HT, Pedersen L. Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen. Acta Oncol 2010; 49(3):305-12.

Clough-Gorr KM, Ganz PA, Silliman RA. Older breast cancer survivors: factors associated with self-reported symptoms of persistent lymphedema over 7 years of follow-up. Breast J. 2010;16(2):147-55.

Clough-Gorr KM, Stuck AE, Thwin SS, Silliman RA. Older breast cancer survivors: geriatric assessment domains are associated with poor tolerance of treatment adverse effects and predict mortality over 7 years of follow-up. J Clin Oncol 2010; 28(3):380-6.

Silliman RA. When cancer in older adults is undermanaged: the breast cancer story. J Am Geriatr Soc 2009; 57 Suppl 2:S259-61. 

Buist DS, Chubak J, Prout M, Yood MU, Bosco JL, Thwin SS, Gold HT, Owusu C, Field TS, Quinn VP, Wei F, Silliman RA. Referral, receipt, and completion of chemotherapy in patients with early-stage breast cancer older than 65 years and at high risk of breast cancer recurrence. J Clin Oncol 2009; 27(27):4508-14.

Mandelblatt JS, Silliman RA. Hanging in the balance: making decisions about the benefits and harms of breast cancer screening among the oldest old without a safety net of scientific evidence. J Clin Oncol 2009; 27(4):487-90.

Clough-Gorr KM, Rakowski W, Clark M, Silliman RA. The Getting-Out-of-Bed (GoB) scale: A measure of motivation and life outlook in older adults with cancer. J Psychosoc Oncol 2009; 27:454-68. PMID: 19813135

Bosco JLF, Lash TL, Prout MN, Buist DSM, Geiger AM, Haque R, Wei F, Sililman RA for the BOW investivators. Breast cancer recurrence in older women five to ten years after diagnosis. Cancer Epidemiol Biomarkers Prev 2009;18:2979-83 {Epub October 20, 2009}. PMID: 19843686

Gold HT, Thwin SS, Buist DSM, Field TS Wei F, Ulcickas Yood M, Lash TL, Quinn V, Geiger AM, Silliman RA for the BOW investigators. Delayed radiotherapy for breast cancer patients in integrated delivery systems. Am H Manag Care 2009;15:785-89. PMID: 19895182

Bosco JLF, Silliman RA, Thwin SS, Geiger AM, Buist DS, Prout MN, Yood MU, Haque R, Wei F, Lash TL. A most stubborn bias: no adjustment method fully resolves confounding by indication in observational studies. J Clin Epidemiol 2009 May 19. PMID: 19457638

Gramling R, Eaton CB, Rothman KJ, Cabral H, Silliman RA, Lash TL. Hormone replacement therapy, family history, and breast cancer risk among postmenopausal women. Epidemiology 2009;20:752-56. PMID: 19451819

Schonberg MA, Silliman RA, Marcantonio ER. Weighing the benefits and burdens of mammography screening among women age 80 years or older. J Clin Oncol 2009;27:1774-80. Epub 2009 Mar 2.  PMID: 19255318

Ahern TP, Lash TL, Thwin SS, Silliman RA.  Impact of acquired comorbidities on all-cause mortality rates among older breast cancer survivors. Med Care 2009;47:73-79. PMID: 19106734

Ahern TP, Bosco JLF, Silliman RA, Ulcickas Yood M, Field TS, Wei F, Lash TL.  Potential misinterpretations caused by collapsing upper categories of comorbidity indices: An illustration from a cohort of older breast cancer survivors.  Clin Epidemiol 2009;1:93-100.

Ulcickas Yood M, Owusu C, Buist DSM, Geiger AM, Field TS, Thwin SS, Lash TL, Prout MN, Frost FJ, Wei F, Quinn VP, Silliman RA.  The mortality impact of less than standard therapy in older breast cancer patients.  J Am Coll Surg 2008;206:66-75.

Field TS, Doubeni C, Fox M, Buist DSM, Wei F, Geiger AM, Quinn VP, Lash TL, Prout MN, Ulcickas Yood M, Frost FJ, Silliman RA. Lower use of surveillance mammography among older breast cancer survivors at elevated risk of recurrence.  J Gen Intern Med 2008: 23:158-63.

Clough-Gorr KM, Fink AK, Silliman RA.  Challenges associated with longitudinal survivorship research: Attrition and a novel approach of reenrollment in a six-year follow-up study of older breast cancer survivors. J Cancer Survivorship 2008;2:95-103.

Lash TL, Pederson L, Cronin-Fenton D, Ahern TP, Rosenberg CL, Lunetta KL, Silliman RA, Hamilton-Dutoit S, Garne JP, Ewertz M, Sørensen HT.  Tamoxifen’s protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram.  Br J Cancer 2008;99:616–621.

Clough-Gorr KM, Silliman RA.  Translation requires evidence: Does cancer-specific CGA lead to better care and outcomes?  Oncology 2008; 22:925-26.

Ethical Considerations

Grace PJ, Hardt EJ. When a patient refuses assistance. Am J Nurs 2008; 108:36-38

Exceptional Longevity

Perls T. Health and disease in people over 85. BMJ 2009; 339:b4715.
doi : 10.1136/bmj/b4715.

Sebastiani P, Hadley EC, Province M, Christensen K Rossi W, Perls TT, Ash AS. A family longevity selection score: ranking siblings by their longevity, size, and availability for study. Am J Epidemiol 2009;170(12):1555-62.

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifestyle in C. elegans. PLoS One 2009; 4(14):e8210.

Givens JL, Frederick M, Silverman L, Anderson S, Senville J, Silver M, Sebastiani P, Terry DF, Costa PT, Perls TT. Personality traits of centenarians' offspring.  J Am Geriatr Soc 2009;57:683-85.  PMID: 19392961

Adams ER, Nolan VG, Andersen SL, Perls TT, Terry DF. Centenarian Offspring: Start Healthier and Stay Healthier.  J Am Geriatr Soc 2008;56:2089-92. 

Terry DF, Nolan VG, Andersen SL, Perls TT, Cawthon R. Association of longer telomeres with better health in centenarians. J Gerontol A Biol Sci Med Sci 2008;63:809-12.

Terry DF, Sebastiani P, Andersen SL, Perls TT. Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch Intern Med 2008;168:277-83.

Geriatric Education

Mostow C, Crosson J, Gordon S, Chapman S, Gonzalez P, Hardt E, Delgado L, James T, David M.Treating and precepting with RESPECT: a relational model addressing race, ethnicity, and culture in medical training. J Gen Intern Med 2010; 25 Suppl 3:S146-54. 

Oates DJ, Norton LE, Russell ML, Chao SH, Hardt EJ, Brett B, Kimball P, Levine SA. Multisite geriatrics clerkship for forth-year medical students: A successfull model for teaching the association of American medical colleges' core competencies. J Am Geriar Soc 2009;57:1917-1924.

Levine SA, Chao SH, Brett B, Jackson AH, Burrows AB, Goldman LN, Caruso LB. Chief resident immersion training in the care of older adults: an innovative interspecialty education and leadership intervention.  J Am Geriatr Soc 2008;56:1140-45.

O'Sullivan P, Chao S, Russell M, Levine S, Fabiny A. Development and Implementation of an Objective Structured Clinical Examination to Provide Formative Feedback on Communication and Interpersonal Skills in Geriatric Training.  J Am Geriatr Soc 2008;56:1730-35. 

Goldman LN, Wiecha J, Hoffman M, Levine SA. Teaching geriatric assessment: use of a hybrid method in a family medicine clerkship. Fam Med. 2008:40:721-25.

Geriatric Medicine

Caruso LB, Silliman RA. Geriatric medicine. In: Fauci AS, Kasper DL, Braunwald E, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison’s Principles of Internal Medicine, 17th edition. New York: McGraw Hill, Medical Publishing Division, 2008:53-66.

Health Literacy

Oates DJ, Silliman RA. Health literacy: improving patient understanding. Oncology 2009;23:376-79. PMID:19476268

Oates DJ, Paasche-Orlow MK. Health literacy: communication strategies to improve patient comprehension of cardiovascular health. Circulation 2009;119:1049-51. PMID: 19237675

Research Methods

Sebastiani P, Perls TT. Prediction models that include genetic data. Circ Cardiovasc Genet 2010; 3(1):1-2.

Sebastiani P, Timofeev N, Dworkis DA, Perls TT, Steinberg MH. Genome-wide association studies and the genetic dissection of complex traits. Am J Hematol 2009; 84:504-15. PMID: 19569043

Sebastiani P, Zhao Z, Abad-Grau MM, Riva A, Hartley SW, Sedgewick AE, Doria A, Montano M, Melista E, Terry D, Perls TT, Steinberg MH, Baldwin CT. A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. BMC Genet 2008;9:6.

Zhao Z, Timofeev N, Hartley SW, Chui DK, Fucharoen S, Steinberg MH, Perls TT, Baldwin CT, Sebastiani P. Imputation of Missing Genotypes: An Empirical Evaluation of IMPUTE. BMC Genet. 2008:12;9:85.

 

 

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