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James L. Kirkland, MD, PhD is Associate Professor of Medicine, Boston University School of Medicine. Dr. Kirkland's research focus is in the effects of age and fat depot site on adipose function. He studies how preadipocytes, the cells that give rise to fat cells, change in function with aging and how they vary among different parts of the body. He has shown that accumulation of fat and changes in gene expression as preadipocytes become fat cells are blunted with aging and that processes inherent to these cells contribute. He has been studying the responsible mechanisms in order to understand how aging affects tissue growth, how fat tissue contributes to diseases such as diabetes and hypertension, and what pathways to target during drug development.
Dr. Kirkland is also Director of the Adipocyte Core of the Boston Obesity/Nutrition Research Center. This Core provides preadipocytes to investigators in the Boston area, prepares products from these cells, and provides consultative advice about experimental design and methods involving these cells.
Recent Publication:
Tchkonia, T., Tchoukalova, Y., Giorgadze, N., Pirtskhalava, T., Karagiannides, I., Forse, R.A., Koo, A., Stevenson, M., Chinnappan, D., Cartwright, A., Jensen, M.D., Kirkland, J.L. Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. American Journal of Physiology 288:E267-E277, 2005.
Key Telephone Numbers
Geriatrics Section Administration: 617-638-8383
Education: 617-638-6115
Mailing Address:
Geriatrics Section , Boston Medical Center
88 East Newton Street, Robinson 2
Boston, MA 02118
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