The Primary Immunodeficiency Clinic diagnoses and cares for patients with immunological conditions for which the cause is unknown. This includes patients with frequent infections and inflammatory and autoimmune diseases that do not respond to treatment. Boston Medical Center immunologists provide cutting-edge autoimmune testing and treatment, including immunoglobulin replacement therapy, precision immunomodulatory infusions, and prophylactic anti-infective agents. Patients with primary immunodeficiency also have the opportunity to participate in clinical trials funded by the National Institutes of Health, Immune Deficiency Foundation, and other organizations.