Otolaryngology – Ear, Nose and Throat Surgery

Cancer Clinical Trials

Please visit the external Boston University Chobanian & Avedisian School of Medicine Cancer Clinical Trials website for information on current research studies in head and neck oncology.

Center for Innovative Technology and Clinical Outcomes Research

The Center for Innovative Technology & Clinical Outcomes Research is located on the 5th floor of the BCD Building.  The research in this center can be grouped into three major areas of work; 1) development and testing of novel imaging technology that enhances clinical care, 2) evaluating the efficacy of clinical interventions, and 3) designing, refining, and testing patient outcome measurement tools.  This center involves a multidisciplinary group of clinicians and researchers who specialize in areas such as head and neck cancer, laryngology, speech language pathology, oral and maxillofacial surgery, pathology, bioengineering and biostatistics.  

Current projects include the following:

1.    ESS R01
2.    ARF R01
3.    Validation of BRACS
4.    3D endoscope development
5.    PAS scale assessment
6.    Variation in dysphagia care
7.    Qualitative Dysphagia Assessment 
8.    Amitriptyline / CLH – assessing efficacy of this med 
 

Early diagnosis of oral cancer using spectroscopic techniques

Early detection of oral cancer is critical for successful treatment and improvement of the survival rate. However, current detection is usually done by visual screening and biopsies. It presents a major challenge for even experienced clinicians. 

Our findings from animal models and patient studies are very encouraging. Now, we are continuing to work on this study to develop new tri-modal spectroscope (a combination of three spectroscopic techniques) and scattering imaging techniques. We expect that our new study will further improve the sensitivity and specificity of diagnosis. We will also explore the feasibility of using these new technologies for intraoperative guidance of tumor surgery and for prediction of the treatment efficacy with cancer chemoprevention.

New chemoprevention strategy for head and neck cancers

Oral cancer is one of the most common neoplasms, and it is estimated that close to 40,000 Americans will be diagnosed with oral or pharyngeal cancer this year and it will cause will cause over 8,000 deaths. Its slow and cumulative process strongly supports the rationale for its prevention. Chemoprevention is a promising strategy, but its widespread use has been hampered by its significant toxic side effects. Anti-angiogenesis has been established as one of the cornerstones of chemoprevention.

Our previous studies have indicated the effectiveness of selective microvascular targeting with a 585 pulsed dye laser (PDL) for tumor inhibition with no damage to neighboring tissue. Importantly, PDL is capable of providing a synergic effect with some routine chemopreventive agents (i.e., retinoic acid) via its ability to selectively destroy existing microvasculature in targeted tissue. In our preliminary studies, a combination of PDL and chemoprevention called laser “photo-chemoprevention,” enabled us to significantly reduce the dose of the chemical agent without sacrificing its efficacy for inhibition of tumor growth. We also are testing a new approach for cancer chemoprevention with less systemic toxicity by topically delivering the agent with polymer “biofilm.” Our long-term goal is to develop new and effective treatment with fewer side effects for chemoprevention or early treatment of cancers.

Novel and less invasive approach for head neck surgery

Our group has been working on testing new laser or other techniques for more than 10 years to develop less invasive surgery or selective targeting therapy for head and neck diseases. Currently, our studies include (1) laser photothermolysis of vocal cord scarring. We are using an antibody-targeted laser photolysis to avoid or reduce hypertrophic scar growth in vocal cords. This method will allow us to apply highly-selective targeting while sparing neighboring tissue from collateral damage with diode laser surgery; and (2) less invasive laser surgery for laryngeal papilloma and vascular lesions. We will use a pulsed dye laser to selectively destroy the lesions while preserving the voice function.

Center for Voice and Swallowing Research

The Center for Voice and Swallowing Research is located on the 5th Floor of the BCD Building 800 Harrison Avenue, with a clinic in the 1st Floor of 830 Harrison Avenue at Boston Medical Center. For more information on this research, please visit the Center for Voice and Swallowing website.